Politically, I hope people finally wake up. Stop the CIA and NSA, they do nothing good for the American people.
Professionally, I'm looking forward to blackhats and whitehats alike using the leaks for new exploits and malware. And I don't just mean vulnerabilities that remain unpatched on purpose. Far more interesting is how hackers will use "government special tactics" themselves.
Haven't read that much of it, though, only summaries and some sneak peaks. Maybe I (or some others here at 0x00sec) could take some practical parts of the docs and make write-ups or POCs of what the CIA's doing.